Forming a stable dispersion of the local anesthetic n‐butyl‐p aminobenzoate ( Butamben) for epidural administration.
 
The purpose of this study is to form a uniform, stable suspension
of n‐butyl‐p‐aminobenzoate which can be used
for epidural administration. All additives used should be approved
for injection in the human body. When precipitated, the particles should be
able to give a homogenous suspension after shaking. Particles produced with
three methods will be compared based on size, release, shape and injectability
through the catheter. The methods used are a microfluidic system.
To produce uniform and stable microparticles a new developed technology
from EmulTech Eindhoven can be used. In this technology, different micro-channels
cross each other, forming the micro‐particles in the outgoing channel.
My question is (What is the best stabilizer that I can used in this
suspense?) Knowing that the size of the particles
must be (1-10) micrometer.
Any ideas??????