Gaithersburg, MD, USA
Posted by: Astra Zeneca
28 Dec

Senior Scientist, Cell Therapy

Gaithersburg, MD, USA
Job Description


We are seeking a highly-motivated and independent Senior Scientist with demonstrated experience in Cellular Therapy, Immunology, and/ or Immuno-Oncology to join our rapidly growing Cell Therapy Team.  In this role you will make use of your experience in T cell immunology to contribute to the advancement of innovative Cell Therapy products by designing and conducting laboratory experiments, developing methodology, and generating and interpreting scientific data in a highly collaborative environment. The role will be based in Gaithersburg, Maryland.



  • Conducts routine drug discovery research experiments independently by applying the techniques of molecular and cellular biology, communicates the results to team members, and is involved in the interpretation of data

  • Supports a team and works collaboratively with project managers to ensure the efficient relay of information and forward translation of data

  • Maintains a well-developed understanding of approaches to drug discovery and applies a broader functional knowledge of the procedures used by diverse project groups to support the department where needed

  • Assesses and reports data, with little or no guidance, in a clear and concise manner, with a clear understanding of its implications within the overall context of drug discovery

  • Provides technical instruction to the team and allocates administrative work where possible

  • Shares relevant external published papers with peers

  • Communicates and shares information between distinct projects within the bioscience function and across other functions

  • Ensures own work, and work of peers, is compliant with Good Laboratory Practice, Safety, Health and Environment standards and all other relevant internal AstraZeneca standards and external regulations

Job ID Reference
Desired Skills & Experience


  • PhD in a relevant discipline with demonstrated experience in Cellular Therapy, Immunology, and/ or Immuno-Oncology

  • Minimum of 3 years of experience in Cellular Therapy, Immunology, and/ or Immuno-Oncology

  • Well-developed understanding of molecular and cellular biology, immunological assays, and cell transfection/ transduction

  • Experience developing cellular therapies including CAR-T/ CAR-NK, TCR-T, and/ or TIL therapies

  • Experience with genome editing technologies (CRISPR/ Cas9, base-editing, transposons, etc.)

  • Multicolour flow cytometry

  • Transfection/ transduction and expansion of primary cells

  • Advanced cell culture techniques

  • Transfection/ transduction and expansion of primary cells

  • Advanced cell culture techniques



  • In vivo skillset including animal handling, mouse tumor models, standard routes of dosing and engraftment

  • Experience with large scale in vitro screening

  • Postdoctoral experience working with primary human T cells

  • Background in drug discovery and development in the pharmaceutical industry

  Gaithersburg, Maryland, USA
AstraZeneca is an exciting global, innovation-driven biopharmaceutical company. We’re inspired by what science can do. Driven by the desire to meet unmet patient needs in our core therapeutic areas. Bold in our thinking. Proactive in pursuing discoveries beyond imagination. At sites across the world, we bring teams together in a spirit of collaboration to turn great ideas into life-changing medicines – strengthening our product portfolio and harnessing the potential of a pipeline across all stages of the drug development process.
You’ll be part of a team that’s rolling back the frontiers of science to turn yesterday’s impossible into the normal of tomorrow. So, if you share our focus and passion, join us and make a difference to patients – and in return, we’ll help you develop way beyond what you thought possible.
 Gaithersburg, MD, USA