Cambridge, UK
Posted by: Astra Zeneca
17 May
16 Jul expires

Tissue Imaging Scientist (Cell Therapy) - Imaging & AI

Cambridge, UK
Job Description

As a Tissue Imaging Scientist (Cell Therapy), you will play a pivotal role in delivering high quality imaging data, employing core histology and advanced molecular techniques, involving immunohistochemistry, immunofluorescence and in situ hybridisation method development and antibody characterisation to support projects. You will be involved in the delivery of the histology component of early investigative in vivo safety studies, working with local imaging hub lead, pathologists and study directors to deliver data to required quality standards and timelines. In addition, you will provide experienced application of imaging technologies to advise on efficacy of new therapies.

The role

As a Tissue Imaging Scientist (Cell Therapy) you will;

  • Lead design of tissue imaging endpoints, primarily with histological and molecular pathology based techniques and provide general and hypothesis-driven scientific advice on specific topics to the team
  • Have a strong understanding of the practices, principles and concepts associated with a variety of study types using both histological/molecular pathology techniques and other tissue imaging technologies within the group
  • Understand the CPSS Cell Therapy strategy and develop appropriate imaging methods to support the delivery of project goals. Work closely with the CPSS Cell Therapy Safety Lead and with individual project teams
  • Analyse and report the data you produce, with little or no guidance, in a clear and concise manner, to colleagues and stakeholders
  • Maintain a knowledge internally and externally of new trends in tissue imaging technology, experimental techniques/equipment and introduce new methods and instrumentation as required and agreed with the Imaging & AI Leadership Team
  • Manage your work to ensure that agreed targets are met to agreed timelines and quality standards
  • Contribute to the objectives of the department through active participation in department and cross-functional project teams/meetings, ensuring that work is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards.
Job ID Reference
Desired Skills & Experience

Essential Requirements:

  • PhD or Graduate (cell biology, molecular biology, biotechnology etc.) with strong experience in relevant role
  • Expert knowledge in at least one of the following: immunohistochemistry, immunofluorescence, in situ hybridisation
  • Knowledge of histomorphology of mammalian tissue/tissues
  • Independent experimental design, critical data analysis (including statistics) and reporting
  • Comprehensive core knowledge of histology techniques
  • Problem-solving skills related to molecular pathology data analysis
  • Excellent communication skills and proven ability to work within a team environment - support for colleagues

Desirable Requirements:

  • Experience in the pharmaceutical industry or hospital molecular pathology laboratory
  • Understanding of CAR-T therapy and application of tissue imaging endpoints in support of safety/efficacy assessment
  • Practical knowledge of multiplex immunohistochemistry/immunofluorescence methodology
  • Experience in image analysis using a commercial software solutions
  • Understanding of other subject areas within pharmaceutical R&D
  • Results driven, focus on timely delivery.
  • Leadership skills within small teams and on individual projects
  Gaithersburg, Maryland, USA
AstraZeneca is an exciting global, innovation-driven biopharmaceutical company. We’re inspired by what science can do. Driven by the desire to meet unmet patient needs in our core therapeutic areas. Bold in our thinking. Proactive in pursuing discoveries beyond imagination. At sites across the world, we bring teams together in a spirit of collaboration to turn great ideas into life-changing medicines – strengthening our product portfolio and harnessing the potential of a pipeline across all stages of the drug development process.
You’ll be part of a team that’s rolling back the frontiers of science to turn yesterday’s impossible into the normal of tomorrow. So, if you share our focus and passion, join us and make a difference to patients – and in return, we’ll help you develop way beyond what you thought possible.
 Cambridge, UK