This role is an opportunity to be part of ground-breaking research at the forefront of human genomics.
This role will focus on the development of innovative and robust statistical methods to analyse large-scale human genomics datasets, and/or on the application of such methods and interpretation and communication of results.
You will be part of a dynamic team in CGR’s multidisciplinary genomics research environment comprising bioinformaticians, computational biologists, genome scientists, software engineers, postdoctoral researchers, disease area specialists.
You will also work closely with specialists in translational science, drug discovery, pre-clinical modelling, and clinical development.
Lead and carry out quantitative genomic analyses on large-scale cohort studies, to identify risk and response associations for diseases of interest
Deliver novel insights into the biology of disease, validation of new targets for medicines and the improvement of selection of patients for clinical trials
Incorporate additional molecular data into genomic analyses such as gene expression data, metabolomics and/or proteomics
Work with sophisticated phenotype data (e.g., electronic health records and clinical trials) to better identify population subgroups of greatest interest
Develop analytical algorithms and tools to address scientific questions with big data
Contribute to publication of results
Support and supervise more junior team members
Ensure all work is follows Good Laboratory Practice, Safety, Health and Environment standards and all internal AstraZeneca standards and external regulations
Doctoral degree (or equivalent experience) in bioinformatics, biostatistics, complex trait genetics, computational biology, statistical genetics or a related field
Have experience in large-scale genetic data analysis, applied statistics, and/or machine learning
Coding skills appropriate for large scale genomics analysis
Understanding or curiosity about the potential of genomics to impact drug discovery
Possess superb communication skills and willingness to work within a team in a quickly evolving environment
Have a track record of peer-reviewed publications in high-level scientific journals
Desirable Criteria
Experience in analysing genome sequencing data
Experience in case-control sequencing based statistical analyses
Familiarity with high performance and/or cloud computing
Experience curating and analysing electronic health data
Experience quantifying and interpreting the clinical relevance of rare variants